Sunday, August 30, 2009

DOBUTAMINE

More about dobutamine


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Dobutamine is a racemate; the (+) isomer produces the beta-1 effect (positive-chronotropic), but minimal cardioacceleration occurs because the (-) isomer is an alpha agonist, which tends to prevent the chronotropic effect (cardioacceleration)

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The result is that cardiac output is increased with minimal increase in heart rate.

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